A part of PEAS Institut @ Söderleden 1, 58723 Linköping, Sweden

NETS – detector

NETs Neutrophil Extracellular Traps
– a means for white blood cells to trap bacteria

dExact is measuring the amount of cell-free DNA. The higher the concentration of cell-free DNA (i.e. NETs), the more severe is the acute infection.

In the video clip we can see what happens when a neutrophil, the most common white blood cell, combats pathogenic bacteria. The neutrophil ”explodes” giving rise to cell-free DNA, making it able to trap circulating bacteria.  It will show you a comparison of a neuthrophil activated by bacteria (left pane) and an inactive neutrophil (right pane). The DNA in the cells is visualised by the blue color. At the end of the clip only the activated neutrophil is shown untill the membrane brakes, leaving the DNA free to trap bacteria.