A part of PEAS Institut @ Söderleden 1, 58723 Linköping, Sweden

Technology – What we measure

Measuring the body’s defense mechanism

When our body is attached by aggressive bacterias, the body has several defense mechanisms. dExact is measuring two of these defense mechanisms, NETs, Neutrophil Extracellulalar Traps, and HGF, Hepatocyte Growth Factor. dExact is therefore measuring the body’s defense reaction to aggresive bacteria and not the type of bacteria.  dExact can separate an acute infection from a chronical infection.

NETs detector

 Neutrophils, the most common type of white blood cells, are the immune system’s first-line of defense against acute bacterial infections. Neutrophil extracellular traps (NETs) are networks of extracellular DNA from neutrophils, which bind and kill pathogen bacteria. NETs allow neutrophils to kill extracellular pathogens while minimizing damage to the host cells. dExact is acting as a NETs detector, measuring the amount of cell free DNA, which is a biomarker for the amount of aggresive bacteria in the organ.

HGF – Hepatocyte Growth Factor

HGF is a protein that stimulates cell division and the healing of wounds. When the body has an acute infection, e.g. the testines are attached by aggresive bacteria, creating small wounds in the testines, the body produces an extraordinary amount of HGF to help the body to repair these wounds. dExact is measuring the amount of HGF in feces, which is a biomarker for the amount of aggresive bacteria in the testines.